diff --git a/tox.ini b/tox.ini
index 980b663bf55bbbf0b9dd0f35951531fdf24e836a..e440a8a7465e6696c00658be2cb9d6882e8ae6e1 100644
--- a/tox.ini
+++ b/tox.ini
@@ -23,3 +23,18 @@ commands = {envpython} -m flake8 {toxinidir} {posargs}
 [flake8]
 max-line-length = 120
 exclude = cubicweb_card/migration/*,.tox/*,
+
+[testenv:pypi-publish]
+basepython = python3
+skip_install = true
+whitelist_externals = rm
+deps =
+  twine
+passenv =
+  TWINE_USERNAME
+  TWINE_PASSWORD
+commands =
+  rm -rf build dist .egg .egg-info
+  python3 setup.py sdist bdist_wheel
+  twine check dist/*
+  twine upload --skip-existing dist/*